Hygiene Hypothesis References: Supporting Science
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1 Bach, J.F. (2002) The effect of infections on susceptibility to autoimmune and allergic diseases. N. Engl. J. Med. 347, 911920
2 Sawczenko, A. et al. (2001) Prospective survey of childhood inflammatory bowel disease in the British Isles. Lancet 357, 10931094
3 Rook, G.A. et al. (2004) Mycobacteria and other environmental organisms as immunomodulators for immunoregulatory disorders. Springer Semin. Immunopathol. 25, 237255
4 Wildin, R.S. et al. (2002) Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome. J. Med. Genet. 39, 537545
5 Akdis, M. et al. (2004) Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells. J. Exp. Med. 199, 15671575
6 Viglietta, V. et al. (2004) Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis.
J. Exp. Med. 199, 971979
7 Kriegel, M.A. et al. (2004) Defective suppressor function of human CD4+ CD25+ regulatory T cells in autoimmune polyglandular syndrome type II. J. Exp. Med. 199, 12851291
8 Powrie, F. et al. (2003) Control of immune pathology by regulatory T cells. Novartis Found. Symp. 252, 9298
9 Kraus, T.A. et al. (2004) Failure to induce oral tolerance to a soluble protein in patients with inflammatory bowel disease. Gastroenterology 126, 17711778
10 Babu, S. et al. (2006) Regulatory networks induced by live parasites impair both Th1 and Th2 pathways in patent lymphatic filariasis: implications for parasite persistence. J. Immunol. 176, 32483256
11 van der Kleij, D. et al. (2002) A novel host-parasite lipid crosstalk. Schistosomal lyso-phosphatidylserine activates Toll-like receptor 2 and affects immune polarization. J. Biol. Chem. 277, 4812248129
12 Smits, H.H. et al. (2005) Selective probiotic bacteria induce IL-10- producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin. J. Allergy Clin. Immunol. 115, 12601267
13 van den Biggelaar, A.H. et al. (2000) Decreased atopy in children infected with Schistosoma haematobium: a role for parasite-induced interleukin-10. Lancet 356, 17231727
14 King, C.L. et al. (1993) Cytokine control of parasite-specific anergy in human lymphatic filariasis. Preferential induction of a regulatory T helper type 2 lymphocyte subset. J. Clin. Invest. 92, 16671673
15 Pasare, C. and Medzhitov, R. (2003) Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science 299, 10331036
16 Zuany-Amorim, C. et al. (2002) Suppression of airway eosinophilia by killed Mycobacterium vaccae-induced allergen-specific regulatory T-cells. Nat. Med. 8, 625629
17 Wilson, M.S. et al. (2005) Suppression of allergic airway inflammation by helminth-induced regulatory T cells. J. Exp. Med. 202, 11991212
18 Ricklin-Gutzwiller, M.E. et al. (2007) Intradermal injection of heat-killed Mycobacterium vaccae in dogs with atopic dermatitis: a multicentre pilot study. Vet. Dermatol. 18, 8793
19 Zaccone, P. et al. (2003) Schistosoma mansoni antigens modulate the activity of the innate immune response and prevent onset of type 1 diabetes. Eur. J. Immunol. 33, 14391449
20 Summers, R.W. et al. (2005) Trichuris suis therapy in Crohns disease. Gut 54, 8790
21 OBrien, S.M. et al. (2004) Cytokines: abnormalities in major depression and implications for pharmacological treatment. Hum. Psychopharmacol. 19, 397403
22 Schiepers, O.J. et al. (2005) Cytokines and major depression. Prog. Neuropsychopharmacol. Biol. Psychiatry 29, 201217
23 Capuron, L. and Miller, A.H. (2004) Cytokines and psychopathology: lessons from interferon-a. Biol. Psychiatry 56, 819824
24 Maes, M. (1999) Major depression and activation of the inflammatory response system. Adv. Exp. Med. Biol. 461, 2546
25 Penninx, B.W. et al. (2003) Inflammatory markers and depressed mood in older persons: results from the Health. Aging and Body Composition study. Biol. Psychiatry 54, 566572
26 Musselman, D.L. et al. (2001) Higher than normal plasma interleukin-6 concentrations in cancer patients with depression: preliminary findings. Am. J. Psychiatry 158, 12521257
27 Raison, C.L. and Miller, A.H. (2003) Depression in cancer: new developments regarding diagnosis and treatment. Biol. Psychiatry 54, 283294
28 Ferketich, A.K. et al. (2005) Depressive symptoms and inflammation among heart failure patients. Am. Heart J. 150, 132136
29 Chapman, D.P. et al. (2005) The vital link between chronic disease and depressive disorders. Prev. Chronic Dis. 2, A14
30 Beuther, D.A. et al. (2006) Obesity and asthma. Am. J. Respir. Crit. Care Med. 174, 112119
31 Maes, M. et al. (1999) Lower serum zinc in major depression in relation to changes in serum acute phase proteins. J. Affect. Disord. 56, 189194
Saved search on Google News for stories relating to the Hygiene Hypothesis. Always up-to-date, without any effort on our part, just like we like it.
A site detailing one practical application of all these theories to autoimmunity, atopy and allergy.
The Wikipedia entry for the hygiene hypothesis.
A Yahoo formum on a related topic, helminthic therapy.